Maxwell Campbell
Computational Biologist, ML Engineer
Hi there, I'm Max. I live in San Francisco. I'm currently a visiting undergraduate in the Bayrer Lab at UCSF, where I work on the gut-brain axis and computational biology.
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Publications
Crowdsourced Protein Design: Lessons From the Adaptyv EGFR Binder Competition
CITATIONS: 31 | MIDDLE AUTHOR | PREPRINT
In this report, we summarize and analyze the 2024 Adaptyv EGFR protein design competition. Participants used computational and ML methods of their choice to design proteins to bind the EGFR, a key drug target that plays a critical role in cell growth, differentiation, and cancer development.
VIPER: A General Model for Prediction of Enzyme Substrates
CITATIONS: 7 | SOLE AUTHOR | PREPRINT
Here, we introduce VIPER (Virtual Interaction Predictor for Enzyme Reactivity), a model that achieves an average 30% improvement over the previous state-of-the-art model (ProSmith) in reaction prediction for unseen substrates.
RustSASA: A Rust Crate for Accelerated Solvent Accessible Surface Area Calculations
CITATIONS: 2 | SOLE AUTHOR | Journal of Open Source Sofrware
RustSASA overcomes the computational bottlenecks of traditional solvent acesssile surface area (SASA) algorithms, achieving up to a 5× speed increase over FreeSASA. RustSASA integrates seamlessly with Python and the MDAnalysis framework.
Projects
- DPXRust:
Github Star(s): 5
DPXRust is a rewrite of the DPX algorithm in Rust. DPX is an algorithm for computing a score that indicates to what degree an atom is buried in a protein structure by finding the distance between every atom and the nearest atom with an ASA/SASA above a threshold.
- RustSASA:
Github Star(s): 21
Ludicrously fast Rust crate for protein solvent accessible surface area (SASA) calculations - 46x faster than Biopython, 7x faster than FreeSASA. Pure Rust with Python bindings, CLI, and MDAnalysis package.
- Hearth:
Github Star(s): 40
Hearth is an ultra-high-performance distributed audio streaming and processing server written in Rust that is 30X faster than Lavalink. Allowing Discord music bots to save thousands on server costs. It comes with its own cross-platform client library called Charcoal to make using it incredibly easy.